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Although the single-arm design without a comparator group maintained on the 0.5-mg dose precludes causal inference regarding incremental benefit, these findings provide RWE that may support clinical decision-making regarding dose intensification in patients with suboptimal control on 0.5-mg semaglutide

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Accordingly, the current study has been initiated to investigate whether SUN alters the expression of key genes engaged in mitochondrial transport and oxidation of LCFA, and if so, whether these alterations should be viewed as a mechanism during development of SUN-induced cardiotoxicity