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While adenosine triphosphate (ATP) signaling was enhanced in cultured DRG neurons treated with exendin-4, capsaicin sensitivity and calcium influx remained unaffected, suggesting GLP-1R predominantly modulating gut motility rather than pain signaling [55]

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Both formulations work through the same GLP-1 receptor mechanism, so both can produce similar heart rate effectsthough individual responses depend partly on genetics and dose titration speed

or identical or nearly identical A drug, a component of which is a bulk drug substance (i.e., active pharmaceutical ingredient) that is a component of an approved drug, unless there is a change that produces for an individual patient a clinical difference , , between the compounded drug and the comparable approved drug. as determined by the prescribing practitioner See Section 503B(d)(2)(A)-(B) (codified at 21 U.S.C