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Berg JM, Geschwind DH

The impact of TXNIP on ferroptosis seems to be manifold, as it downregulates SLC7A11 and GPX4 levels [108,122] , increases the labile iron pool via NCOA4-mediated ferritinophagy [123,124] , and disrupts GSH synthesis (Figure 3) [112]

In response, the brain elicits a neuroprotective, purinergic-receptor-dependent inflammatory response characterized by meningeal neutrophil swarming and microglial reconstitution of the damaged glial limitans

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