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Rat studies demonstrated 64.5% reduction in wound size compared to 45.6% for vehicle-treated and 28.2% for control groups, accompanied by significantly lower inflammatory markers
Gaetz et al., 2014
Overexpression of Bcl-2, an anti-apoptotic protein, inhibits autophagy by binding to Beclin 1 and reducing PI3K activity [214, 215], underscoring the therapeutic potential of targeting this axis in cancer treatment
Lower binding energy between the macromolecular protein and small molecule ligand indicates a higher binding probability and stability
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