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Hypertension, ischemic heart disease, patients with atherosclerosis and coronary artery disease, diabetes, chronic lung diseases, smoking and obesity are associated with low baseline GSH levels and reduced GSH/oxidized glutathione (GSSG) ratios (Khanfar and Al Qaroot, 2020

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Compromising NADPH Supply Induces Oxidative Stress To determine the cause of 6AN cytotoxicity, levels of antioxidant molecules NADPH and GSH were determined in 6AN-treated OPCs

We further outline future perspectives such as hybrid multifunctional nanoplatforms, patient-specific redox profiling, and clinical pathways for regulatory approval