menopause and microdosing glp 1 GLP-1 Weight Loss in Menopause: How HRT Amplifies Results Starting a GLP-1 in Perimenopause

Spacing drinks out helps, mostly because the timing is less predictable

Si J, Yu K, Hao J, Wang J, Zhang L (2025) The therapeutic effects and mechanisms of glucagon-like peptide-1 receptor agonists in neurocognitive disorders

Hyperglycemia induces metabolic and cellular stress that drives VEGF signaling, mitochondrial superoxide production, and induces persistent epigenetic changes, thereby priming inflammatory signaling in glia and endothelial cells ( In human retinal endothelial cells, high glucose is associated with lipidomic shifts consistent with increased PUFA oxidation that promote NADPH oxidase activation and tight-junction disruption

Tesamorelin has FDA approval for adult visceral fat reduction and Phase III trial data showing 15% reduction over 26 weeks