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The human CHAC2 protein predates CHAC1, with the two sharing only 50% sequence identity ( 6 YGS 8 motif within the GCT fold are located in loop 1, while the unique dimerization loop 2 is flipped away from the enzymes core domain ( 74 to glutamine (Q) also induced helical formation in the CHAC2 loop 2, suggesting it might be the catalytically relevant glutamate residue that alternates with E 83 ( 2 CHAC1 as a central integrator of glutathione homeostasis, stress signaling and ferroptosis Glutathione homeostasis is essential for cellular and organismal health due to its central role in maintaining redox balance

However, we now know that these long needles are excessive