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Microdosing is a lower-stakes medical introduction that goes below the standard dose of any drug
The Jastreboff Phase 2 trial randomised 338 adults with body mass index 30 (or 27 with at least one weight-related condition) to retatrutide 1, 4, 8, or 12 mg subcutaneously once weekly, or placebo, for 48 weeks
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The mechanism is not fully understood, but inflammation, abnormality of the guts mechanoreceptors and emotional states such as hypervigilance and stress likely play a role (39)
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