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Distinct alterations of hypothalamic proteomic profiles by GLP1/E in lean and obese PCOS mice Finally, considering that the hypothalamus is likely the primary target of the GLP1/E conjugate, we assessed changes in global hypothalamic proteome in PWA and PNA mice following GLP1/E treatment, using cutting-edge liquid chromatographytandem mass spectrometry (LC-MS/MS)

GLP-1 is a secreted hormone with multiple effects upon the intestine (gastric motility), pancreas (glucose dependent insulin release) and hypothalamic pituitary axis (modulates LH, THS, CRH, ocytocin and vasopressin secretion)