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Nonetheless, the magnitude of weight reduction observed at higher doses is notable given that achieving substantial weight loss in individuals with type 2 diabetes has historically been more difficult than in those with obesity alone, partly due to the metabolic effects of the condition itself and certain antidiabetic medications

Am J Physiol Gastrointest Liver Physiol 2012

One-year treatment with liraglutide improved renal function in patients with type 2 diabetes: a pilot prospective study

Si bien ese resultado es coherente con el concepto de continuidad teraputica en intervenciones incretnicas, en Mxico la indicacin aprobada es control glucmico en diabetes tipo 2, y cualquier extrapolacin a otras metas debe alinearse a regulacin y guas clnicas locales. En el ensayo SURMOUNT4 (fase 3, aleatorizado, retirada), tras 36 semanas iniciales con tirzepatida, quienes continuaron el frmaco mantuvieron y aumentaron la prdida de peso en las 52 semanas siguientes, mientras que quienes cambiaron a placebo recuperaron una fraccin relevante del peso perdido