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For research-grade material, lyophilized powder is stable at -20 degrees C for extended periods

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Some investigators found reduced levels of Progranulin (PGRN) in renal biopsies from DKD patients and in the kidneys of DM mice, and using PGRN-deficient mice and HG-induced human podocyte models, PGRN was found to prevent podocyte damage in DKD by promoting mitophagy and mitochondrial biogenesis [112]