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In clinical trials, 100% of healthy volunteers experienced this chromaturia with administration of 5g hydroxocobalamin with other common effects including erythema, rash (predominantly acneiform appearance) and increased blood pressure
This characteristic distinguishes it from sterile water for research, which lacks a preservative and is typically intended for single-use applications to maintain sterility
If you develop diarrhoea after starting B12 supplementation, it is worth considering other factors that may be contributing to your symptoms
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