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After that, it was found that the specific sequence of GLP-1 has insulinotropic effect: GLP-1 (7-36) amide

Potential risks of bias were assessed for all studies using tools specifically developed for this purpose, such as the RoB 2 (revised Cochrane risk-of-bias tool for randomized trials).11 This tool assesses bias on 5 different domains: bias from randomization, bias due to deviations from planned intervention, bias due to lack of outcome data, bias of outcome measurement, and selection bias of reported outcome

Participants receiving the highest dose (15 mg weekly) achieved an average weight loss of approximately 20.9% of baseline body weight over 72 weekssubstantially greater than placebo

It is worth stating that the gut microbiota and their derived metabolites are critical in maintaining normal intestinal permeability