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Hormones and Reproduction of Vertebrates
In populations with added comorbidities, results are lower: TRIUMPH-2 (obesity + diabetes) showed 20.8%, TRIUMPH-3 (obesity + cardiovascular disease) showed 22.6%, and TRANSCEND-T2D-1 (diabetes-specific, 40 weeks) showed 16.8% all consistent with patterns seen across the GLP-1 drug class, where comorbidities reduce achievable weight loss
Interaction effects between the nutritional state and carnitine levels were observed in the mRNA levels of ACC, FAS , and DGAT2 in liver and muscle, and ATGL and LPL in liver (Supplemental Table 3), showing nutritional state and L-carnitine both regulated the lipid synthesis and lipolysis
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