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The team defined discontinuation as a gap of more than 60 days between prescription refills
The analysis further noted that the safety advantage of the combination of GLP-1 RA & Metformin is mechanistically rooted in complementary pathways where metformin's AMPK-mediated suppression of hepatic gluconeogenesis and enhancement of peripheral glucose uptake, alongside GLP-1 RA's glucose-dependent insulin secretion and modulation of gastric motility, together prevent excessive gastric emptying delay that drives GI intolerance
Monitor for interactions: While peptides and GLP-1s work through different mechanisms, individual responses vary
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