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[Abstract]2026 Mar 11;148(9):10225-10240
The PIONEER 7 trial showed Rybelsus 14 mg reduced A1C by ~1.5% and body weight by ~4.4 kg
A prominent group within the top scoring targets are matrix metalloproteinases (MMPs), which include representatives from multiple subgroups: collagenases MMP-1 and MMP-13, stromelysin MMP-3, gelatinase MMP-9, and MMP-12 (Sekhon, 2010)
Hypoglycemia: Patients receiving Trulicity in combination with an insulin secretagogue (e.g., sulfonylurea) or insulin may have an increased risk of hypoglycemia, including severe hypoglycemia
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