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In a randomized controlled trial of 72 patients with type 2 diabetes and reduced heart rate variability, oral supplementation with 800 mg/day of lipoic acid for four months resulted in significant improvement in two out of four measures of heart rate variability compared to placebo (81)

Healthcare providers can prescribe both medications together when clinically indicated, but this combination necessitates enhanced glucose monitoring, particularly during niacin initiation or dose escalation

However, some studies have found that the level of carnitine is not significantly correlated with depression