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Almost 63% of participants who received semaglutide had steatohepatitis resolution without their fibrosis getting worse
stopping or reducing dose typically causes weight regain) The pattern we see in patients who successfully reduce dose: they do it gradually (14 mg to 7 mg over 4 weeks, not abruptly), they maintain strict diet and exercise habits during the transition, and they monitor weight weekly to catch early regain
One of the key challenges for both studies was whether the drugs reach the brain
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