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Real-world pharmacovigilance data is broadly consistent with these findings, though isolated case reports exist for both medications

Expression of peroxisome proliferator-activated receptor- in key neuronal subsets regulating glucose metabolism and energy homeostasis

This has the potential to modulate downstream signalling by directing the ligand towards GLP-1Rs situated in sub-microscopic membrane domains variably enriched with signalling effectors on the cytoplasmic side (Villar et al ., 2016)

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