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PMID: 29753035 Rich, D.S
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Antimicrobial PhotoDynamic Therapy (aPDT) relies on the application of a photosensitizer able to absorb appropriate wavelengths in the visible light range and to react with oxygen molecules inside and around cells, resulting in the production of singlet oxygen or other cytotoxic reactive oxygen species (ROS), which lead to cell death, after inducing photodamage
Support for this notion comes from instructive pathological feature found at the other end of the temporal spectrum, the so-called pre-active lesion, consisting of small clusters of activated microglia seen throughout the MS NAWM, accompanied by axonal and oligodendroglial injury (van Noort et al., 2011
