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262 The excessive production of ROS, including superoxide, hydrogen peroxide (H 2 O 2 ), hydroxyl radicals (OH), and NADPH-oxidase (NOX), combined with reduced antioxidant capacity, contributes to a pathological imbalance that leads to oxidative stress and inflammation
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injections of semaglutide reduced the composite risk for major cardiovascular events (MACE) by 20% compared to placebo
This is consistent with B12 role in energy metabolism and with the depletion pattern described above
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