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In detail, elevation of HDAC6 promotes the formation of aggresome, which emerges as a cytoprotective response in the clearance of toxic misfolded protein aggregates found in neurodegenerative disease such as Parkinsons disease [90], via binding polyubiquitinated misfolded protein including CFTR-F508 [91]
Lysosomal cysteine proteases: facts and opportunities
It has also been observed that GPx expression is diminished in the plasma of patients with end-stage renal diseases [Citation3739]
& Stumpp, M
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