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From the payer perspective, the adjusted total cost per patient for the GLP-1RA group was higher than that for the insulin group by US$969, and from the healthcare sector perspective, the adjusted total cost per patient for the GLP-1RA group was lower than that for the insulin group by US$342

Mahendiratta S, Sarma P, Kaur H, et al

While direct cortisol measurements were not specifically reported in the published safety trials, the comprehensive metabolic monitoring across 900+ participants showed no clinically significant hormonal changes, and the mechanism of action provides no pathway for cortisol stimulation

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