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One hypothesis from researchers at Harvard Medical School: chronic NNMT suppression might alter methylation donor availability, since NNMT consumes S-adenosylmethionine (SAM) as a methyl donor
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doi: 10.3390/nu13061876 21
These compounds work through multiple complementary mechanisms rather than single-target effects, which contributes to their broad therapeutic applications but complicates the standardized testing protocols that regulatory agencies prefer
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