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It has been speculated that by promoting glucosuria and volume depletion, they can cause hemo-concentration in patients that are already at increased risk for peripheral artery disease, resulting in an increased risk for amputation (Das et al, 2018
They are often related to dehydration, reduced caloric intake, or caffeine withdrawal if coffee consumption decreases alongside overall food intake
11 , e201700377 (2018)
Since there are no approved medicines, pills, or procedures that increase melanin production, many people tan in the sun or in indoor tanning beds to stimulate cells to produce more pigment
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