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Since spermatogenesis takes approximately 74 days, complete optimization typically requires 3-4 months of therapy

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Caloric restriction mimicry: Some investigators have noted that the metabolic effects of glutathione repletion in older adults improved insulin sensitivity, reduced inflammation, enhanced mitochondrial function overlap substantially with known benefits of caloric restriction, suggesting that glutathione deficiency may partly mediate the metabolic decline of aging [10][11]

These findings have attracted interest from researchers studying regenerative medicine and aging biology, although much of this work remains preclinical