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Methods: We use mathematical models for hepatic glutathione metabolism, including one-carbon metabolism and acetaminophen detoxification, to investigate how the activation of certain enzymes by estradiol leads to dramatic changes in reaction velocities and metabolite concentrations

Pregnancy or actively trying to conceive : these medications are not studied in pregnant women and must be discontinued at least 2 months before conception

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Metabolic adaptation during GLP-1 therapy is less severe than with traditional dieting, which is one of the major advantages of GLP-1 medications