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In PCOS, oxidative stress contributes to: Hormonal disruption Insulin resistance Inflammation Poor skin recovery Pigmentation flare-ups Glutathione helps by: Reducing free radical damage Supporting cellular repair Calming stress-driven melanin activity This is why skin issues in PCOS often improve after internal balance improves , not before
It has been proposed that overexpression of GPX8 reduces Ca 2+ storage and histamine-induced Ca 2+ release in the endoplasmic reticulum (Yoboue et al., 2017)
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Glutathione peroxidases (GPx, EC 1.11.1.9) Glutathione Peroxidase (GPx) is an important intracellular enzyme that breakdown hydrogen peroxides (H2O2) to water
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