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Given the potential role of GSH in the regulation of immune functions 43,44 and the distinct expression of Gclc in mature B cell subsets, we studied FoB and MZB activation in the presence of buthionine sulfoximine (BSO), a Gclc inhibitor 45
The presence of diabetes did not meaningfully affect these results, suggesting that these benefits were not unique to patients with diabetes. The study included 229 patients with RA and overweight or obesity (BMI 27) who were prescribed a GLP-1 RA between 2018 and 2024
By harnessing the complementary biology of two endogenous hormones, these agents achieve metabolic effects on glycemia, body weight, lipid handling, and cardiovascular risk that neither hormone can fully replicate alone
Thus, the growth in GLP-1 RA prescribing among patients with PCOS may reflect a combination of general expansion in GLP-1 RA use and the high prevalence of metabolic indications in this population
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