After GH therapy, the life quality of these patients with pituitary tumors is improved to an extent (Murray et al., 2002)
The exact combination has not been tested in humans, so the combined picture is built by adding each compound's known signals together
The peptides structure may partially unfold, rendering it less effective
GH accelerates oncogenic signaling for common oncogenic processes and tumor development, including proliferation, migration, invasion (Brunet-Dunand et al., 2009), metastasis (Brittain et al., 2017), and epithelial-to-mesenchymal transition (EMT) (Mukhina et al., 2004), and prevents apoptosis by exerting autocrine or paracrine effects on cancer cell behavior and neighboring cells within the tumor microenvironments (Perry et al., 2017)