Across GLP-1 trials, about 60% of lost weight returns within the first year and roughly 75% returns over the longer curve, with the fastest regain in the early months. The semaglutide extension follows the same direction. The pattern reflects removal of appetite suppression after major weight loss
Two separately opened vials, by contrast, are exposed to repeated septum punctures, ambient temperature excursions during handling, and the cumulative oxidative load that comes with each reconstitution event
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