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Its short half-life, however, required it to be injected several times a day, which limited its appeal as a drug, and the company ran out of funding

Some protocols incorporate topical application to specific areas of concern alongside injectable administration for localized plus systemic benefits

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Patients who do respond meaningfully to the combination may continue cycling AOD-9604 in defined patterns (typically with the 4 to 8 week break between cycles) for as long as the response remains clinically useful