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As concerns fibrosis evaluation through cross-sectional imaging techniques, especially magnetic resonance elastography, their use is limited at the moment to tertiary referral centers and for experimental studies, in light of their cost, the limited availability and the procedural length

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Morphologically, degeneration and death of astrocytes are known as clasmatodendrosis (from Greek , fragment, , tree, , process), described, for the first time, by Alois Alzheimer, who found disintegrating, fragmented processes of astrocytes and oligodendrocytes in epilepsy, neurosyphilis and dementia