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The CKB gene is located on chromosome 14q32.33 and is composed of 7 exons that generate two alternatively spliced mRNAs encoding proteins of 381 amino acids (isoform 1) and 405 amino acids (isoform 2)

Analyzing nine studies that met the inclusion criteria, we found that TCMPs not only significantly alleviated the clinical symptoms and bone destruction indices of RA but also profoundly influenced the structure and metabolic function of the gut microbiota

Weeks 4 to 8: Improvements either plateau or persist