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Short-acting formulations such as exenatide (Byetta) and lixisenatide (Lyxumia) have half-lives of approximately 24 hours
FDA, **Orforglipron** is the **first oral (non-peptide) GLP-1 receptor agonist** designed for chronic weight management in adults with obesity or overweight accompanied by weight-related comorbidities
Subsequently the peptide was identified in rodents to be overexpressed in response to fasting and also elevated in genetically obese mice ( ob/ob mice)
B12 injections, when administered as recommended, pose a low risk of overdose
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