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Discontinuation due to factors typically irrelevant in clinical trial settings (i.e., cost or insurance-related issues and medication shortages) could contribute to the substantial discrepancy between discontinuation rates in pivotal phase 3 trials and those reported in real-world studies. Regarding discontinuation due to side effects, Gasoyan says we do not currently know of patient-level predictors that would help identify who might experience side effects and why
This adhesion is mediated through interactions with mucosal lipid moieties and components of the bacterial cell wall, thereby stabilizing the probiotics association with the intestinal epithelium and facilitating sustained hostmicrobe communication (184, 185)
It also contains phosphatidylcholine, which is beneficial for the liver
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