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Johnson MB, Young AD, Marriott I (2017) The therapeutic potential of targeting substance P/NK-1R interactions in inflammatory CNS disorders

Unlike growth hormone peptides (which work through the pituitary) or GLP-1 peptides (which work through gut and brain receptors), BPC-157 works primarily through a different mechanism: it upregulates growth hormone receptors in tendon cells, stimulates angiogenesis (the formation of new blood vessels), and modulates nitric oxide signaling all of which contribute to accelerated tissue repair and reduced inflammation

Amino Acids, 57 (1), Article 25

Both methods have their perks, but we need more research to know which one wins the prize