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Accordingly, a modality-oriented framework is required to identify exercise-responsive signals with the strongest mechanistic relevance to DR, while acknowledging that evidence remains incomplete for several pathways ( Table 2 )

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*Correspondence: Taiga Miyazaki, [email protected] Shintaro Shimamura, [email protected] This article was submitted to Fungi and Their Interactions, a section of the journal Frontiers in Microbiology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers