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Emerging evidence indicates that dependence can be shaped by metastatic niche, antioxidant nutrient availability and tumor genotype (for example, NRF2/KEAP1 signaling, baseline GPX4 expression and lipid composition)
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Neurological: Neuroprotective pathway exploration and CNS repair modelling
Healthcare providers are advised to weigh both the cardiometabolic benefits and potential risks when prescribing to this group
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