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A slow, controlled injection helps the tissue absorb the liquid more gently, leading to a much more pleasant experience
Different from cI, no proton is translocated for the reactions that occur in cII (Rutter et al., 2010)
The microchannels created by needling allow the peptide to bypass the skin barrier and penetrate directly into the dermis dramatically increasing absorption compared to surface application alone
Vigorous shaking introduces unnecessary foam and air bubbles while exposing the peptide solution to mechanical stress
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