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Both peptides aim to reduce body weight and improve metabolic health through completely different biological mechanisms
Developed to treat type 2 diabetes and obesity, these drugs have drawn attention because GLP-1 receptors are found not only in areas involved in metabolic regulation but also in brain regions associated with reward and reinforcement
Cardiovascular stability is essential for safe donation
To explore the substrate-binding sites in both the dimeric and stacked assemblies, we superimposed the COP1 WD40 with Trib1 (homolog of Drosophila tribbles), which are adaptors for C/EBP degradation (PDB: 5IGQ) onto the individual COP1 WD40 domain in these two states of structures (Supplementary Fig
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