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It is produced by the liver and plays a vital role in many body processes like tissue building and repair, making chemicals and proteins needed in the body, and in immune system function
The mitochondrial-encoded peptide mots-c translocates to the nucleus to regulate nuclear gene expression in response to metabolic stress
Liraglutide also induction HO-1 expression by activating AMPK and promoting HIF-1 protein export from cytoplasm to nucleus, which significantly increases the expression of anti-apoptotic protein Bcl-2 and decreases the expression of pro-apoptotic Bax and Caspase-3 in HUVECs cells [134]
Almaimani, R
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