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In addition, increases in proinflammatory cytokines leads to the formation of amyloid fibrin microclots resistant to fibrinolysis, either by increased production of serum amyloid A (SAA) or by the release of -amyloid (A) peptide by platelets, causing capillary blockage

Beyond Month 6: Maintenance Most patients continue at 2.4 milligrams weekly through month 12, when full clinical trial endpoints are typically reached

Warning signs may include breathing difficulty, severe rashes, swelling, dizziness, chest discomfort, or persistent vomiting