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Here is why: GLP-1 Activation: Not many treatments act like glucagon-like peptide-1 hormones
The classic hospital KD protocol involves a 2448-h fast to induce metabolic ketosis, after which the KD ratio is gradually increased, starting with a 1:1 ratio (1 g of fat per 1 g of protein and carbohydrates), until a 4:1 ratio is achieved (61, 64, 65)
This means you need to push through the initial side effect window to reach the benefit window
This was supported in 5xFAD mice, in which exendin-4 treatment alleviated cognitive dysfunction, prevented amyloid- accumulation, and protected mitochondrial function [54]
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