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Semaglutide is indicated for people with obesity (BMI over 30) or overweight with weight-related comorbidities (BMI over 27)
W.MahadevanL
In a 3-month randomized controlled study of type 2 diabetes, it was found that the combination of liraglutide and sitagliptin had no effect on the composition of intestinal flora, had no effect on the alpha and beta diversity, but liraglutide resulted in an elevation of deoxycholic acid (DCA) levels, indicating potential modulation of bile acid metabolism (Smits et al., 2021)
It is important to note that most concerns about nutrient status with GLP-1 therapy relate to reduced dietary intake rather than direct malabsorption
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