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Eldely population are at risk of developing melanosis coli especially those with chronic constipation [3]
Severe niacin deficiency, known as pellagra, has been historically associated with poverty and consumption of a diet predominantly based on corn, which is low in bioavailable niacin (25, 26)
The underlying mechanism involves the Wnt/beta-catenin signaling pathway, which plays a key role in the regulation of the hair cycle
These observations highlight the suitability of the HepG2 model to study these events and the necessity to define cellular sensors and signaling cascades involved in the NFT-induced increase of glutathione levels
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