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Made by Novo Nordisk, Ozempic is one of several GLP-1 agonists taking the world by storm for its weight-loss benefits
Target engagement by the drug is the first step in the effect cascade, thus understanding the relative occupancy to GLP1R versus GCGR is of great importance
This regular timing is good for two main reasons
Thus, the demonstrated kinetics of generation and decay of the metabolites monitored followed the anticipated precursorproduct relationships, and were entirely consistent with the initial microbial conversion of l-carnitine to BB, followed by transformation of BB to TMA, reaction kinetics akin to the dynamics of l-carnitine catabolism observed with the human commensals P
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