Additionally, intracerebroventricular delivery of Ex-4 has been found to dose-dependently attenuate cue-evoked dopamine activity, further underscoring the direct influence of GLP-1R signaling on neural circuits governing reinforcement and motivation (Konanur et al., 2020)
Polonsky, PhD, CDCES, and Susan Guzman, PhD , from the Behavioral Diabetes Institute reveal the hidden psychosocial forces that drive or derail diabetes self-management
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Moreover, our study revealed that GLP-1 analogs, including GLP-1, liraglutide, and exendin-4, along with the GLP-1 antagonist exendin 939, derived from exendin-4, which shares 53% sequence homology with native GLP-1 39 , effectively inhibited CAP-induced TRPV1 activation in mouse DRG neurons