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In the early 21st century, when no disease-modifying treatments for AD were available, diagnostic biomarkers with mechanistic specificity, such as CSF A 142 /tau ratios or amyloid PET imaging, began to serve a dual role as selection biomarkers in clinical trials
New England Journal of Medicine (2022) 4
Bei topischer Anwendung zeigen sich erste sichtbare Verbesserungen der Hautstruktur nach 46 Wochen , volle Effekte (Faltenreduktion, Elastizitt) nach 12 Wochen
6-month RCT (n = 54) documented dose- and time-dependent increases in body glutathione stores, with the 1,000 mg/day group achieving 30-35% increases in erythrocyte, plasma, and lymphocyte GSH and a 260% increase in buccal mucosal cells
