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Firstly, using the CPRD allowed for the ability to adjust for important potential confounders, including cardiovascular risk factors, microvascular and macrovascular complications, body mass index, and laboratory measures, which are often unavailable in other datasets

Gastrointestinal side effects, including nausea, constipation, diarrhea, and vomiting, were the most common complaint in both groups and were generally mild to moderate, occurring mostly during the dose escalation phase.[1] Injection site reactions were more common with tirzepatide (8.6% vs

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A phase I trial of Gynostemma pentaphyllum in healthy volunteers